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Synlett 2013; 24(19): 2596-2600
DOI: 10.1055/s-0033-1339898
DOI: 10.1055/s-0033-1339898
letter
Study on the Influence of a Sustainable Medium for the Design of Multistep Processes: Three-Component Synthesis of 2-Nitroamines
Further Information
Publication History
Received: 23 July 2013
Accepted after revision: 05 September 2013
Publication Date:
16 October 2013 (online)
Abstract
An environmentally benign method was developed for the three-component, one-pot synthesis of 2-nitroamines by heating a solution of an aldehyde, an aromatic amine, and a nitroalkane in 20% water–methanol at 60 °C for five hours in the absence of a catalyst.
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All 2-nitroamines 5 synthesized are known compounds, see: