Synlett 2013; 24(18): 2393-2396
DOI: 10.1055/s-0033-1339839
letter
© Georg Thieme Verlag Stuttgart · New York

Phase-Transfer Catalysis: Mixing Effects in Continuous-Flow Liquid/Liquid O- and S-Alkylation Processes

Benedikt Reichart
Christian Doppler Laboratory for Flow Chemistry (CDLFC) and Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria   Fax: +43(316)3809840   Email: toma.glasnov@uni-graz.at   Email: oliver.kappe@uni-graz.at
,
C. Oliver Kappe*
Christian Doppler Laboratory for Flow Chemistry (CDLFC) and Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria   Fax: +43(316)3809840   Email: toma.glasnov@uni-graz.at   Email: oliver.kappe@uni-graz.at
,
Toma N. Glasnov*
Christian Doppler Laboratory for Flow Chemistry (CDLFC) and Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria   Fax: +43(316)3809840   Email: toma.glasnov@uni-graz.at   Email: oliver.kappe@uni-graz.at
› Author Affiliations
Further Information

Publication History

Received: 05 August 2013

Accepted after revision: 22 August 2013

Publication Date:
13 September 2013 (online)


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Abstract

This article describes detailed studies on the importance of mixing effects in the O- and S-alkylation of selected phenol and thiophenol substrates. Direct comparison between various continuous-flow reactors and a batch microwave reactor demonstrates the excellent mixing properties of the flow devices, which improve the reaction outcome.

Supporting Information