Facile Synthesis of 2-Fluoro-1,3-dicarbonyl Compounds with Aqueous Hydrofluoric Acid Mediated by Iodosylarenes

Abstract

Direct fluorination of 1,3-dicarbonyl compounds including 1,3-diketones, 3-oxo esters, and 3-oxoamides was conducted using aqueous hydrofluoric acid with the aid of iodosylarenes, giving the corresponding 2-fluorinated products in good to high yields. Among the used iodosylarenes, o-iodosyltoluene was found to be the most effective, and the yield of 2-fluorinated products was improved.

Key words

fluorination - hypervalent iodine - 1,3-dicarbonyl compound - iodosylarene - hydrofluoric acid

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