Synlett 2013; 24(15): 2009-2013
DOI: 10.1055/s-0033-1339447
letter
© Georg Thieme Verlag Stuttgart · New York

An Efficient Oxidative Cross-Coupling Reaction between C–H and N–H Bonds; A Transition-Metal-Free Protocol at Room Temperature

Yinuo Wu
a   State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong
,
Fuk Yee Kwong
a   State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong
,
Pengfei Li*
a   State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong
b   Department of Chemistry, South University of Science and Technology of China, Shenzhen, Guangdong, P. R. of China    Fax: +86(755)86245672   Email: flyli1980@gmail.com
,
Albert S. C. Chan*
c   Institute of Creativity, Faculty of Science, Hong Kong Baptist University, Hong Kong   Email: ascchan@hkbu.edu.hk
› Author Affiliations
Further Information

Publication History

Received: 20 May 2013

Accepted after revision: 18 June 2013

Publication Date:
08 August 2013 (online)


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Abstract

A transition-metal-free oxidative coupling of allylic C–H and heterocyclic/aromatic N–H bonds was performed under mild conditions. Promoted by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), up to 99% yield could be achieved.

Supporting Information