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Synlett 2014; 25(12): 1735-1738
DOI: 10.1055/s-0033-1339112
DOI: 10.1055/s-0033-1339112
letter
Asymmetric Henry Reaction Catalyzed by a Chiral Dinuclear Nickel Complex
Further Information
Publication History
Received: 22 March 2014
Accepted after revision: 18 April 2014
Publication Date:
05 June 2014 (online)
Abstract
Several chiral polyfunctional ligands were conveniently synthesized from l-amino acids and used to prepare the dinuclear complex in situ. A novel bimetallic catalyst containing dinuclear nickel was developed and applied to the asymmetric Henry reaction. With the assistance of N-methylmorpholine, good enantioselectivities (up to 91% ee) and moderate yields (up to 72%) were obtained for aryl, heteroaryl, and aliphatic aldehydes. The pathway was air tolerant and easily manipulated, and the reagents were readily available.
Key words
asymmetric catalysis - bimetallic catalyst - nickel - Henry reaction - nitroaldol reactionSupporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
-
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For reviews on the asymmetric Henry reaction, see:
With Zn:
With Cu:
With Cr:
Other selected examples of asymmetric catalysis using dinuclear Zinc complex, see: