Synlett 2013; 24(19): 2601-2605
DOI: 10.1055/s-0033-1338984
letter
© Georg Thieme Verlag Stuttgart · New York

Bromodimethylsulfonium Bromide (BDMS)-Catalyzed Synthesis of 1,5-Benzodiazepines Using a Multi-Component Reaction Strategy

Satavisha Sarkar
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India   Fax: +91(361)2582349   Email: atk@iitg.ernet.in
,
Jugal Kishore Rai Deka
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India   Fax: +91(361)2582349   Email: atk@iitg.ernet.in
,
Jagadish P. Hazra
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India   Fax: +91(361)2582349   Email: atk@iitg.ernet.in
,
Abu T. Khan*
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India   Fax: +91(361)2582349   Email: atk@iitg.ernet.in
› Author Affiliations
Further Information

Publication History

Received: 14 August 2013

Accepted after revision: 08 September 2013

Publication Date:
14 October 2013 (online)


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This work is dedicated to the late Dr. Uttara Debi who was compassionate and amicable in nature.

Abstract

A new approach for the synthesis of multi-functionalized 1,5-benzodiazepines is developed starting from o-phenylenediamines, β-keto esters and aromatic aldehydes utilizing a one-pot, three-component strategy employing bromodimethylsulfonium bromide as the catalyst. The simple reaction procedure, good yields, mild reaction conditions and applicability to a wide range of substrates are some of the salient features of this protocol.

Supporting Information