2-Cyanoacetamide

Introduction

Cyanoacetic acid derivatives are important intermediates in the synthesis of various organic heterocyclic compounds. Among these derivatives, 2-cyanoacetamide deserves attention since it is a useful reagent for the synthesis of a variety of novel compounds possessing ­biological activity and other special properties.[1]

It possesses electrophilic C1 and C3 carbons and nucleophilic C2 and NH centers responsible for the high reactivity and importance of this compound. The acidic C2 hydrogen prompts an extensive application in a variety of condensation and cycloaddition reactions. Moreover, 2-cyanoacetamide can take part in substitution reactions.[2]

• References

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