Synthesis of (+)-Muricatacin and a Formal Synthesis of CMI-977 from l-Malic Acid

Maria González; Zoila Gándara; Andrea Martínez; Generosa Gómez; Yagamare Fall

doi:10.1055/s-0033-1338934

Synthesis, Table of Contents

Synthesis 2013; 45(12): 1693-1700
DOI: 10.1055/s-0033-1338934

paper

Synthesis of (+)-Muricatacin and a Formal Synthesis of CMI-977 from l-Malic Acid

Maria González

Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain Fax: +34(986)812262 Email: yagamare@uvigo.es Email: ggomez@uvigo.es

,

Zoila Gándara

Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain Fax: +34(986)812262 Email: yagamare@uvigo.es Email: ggomez@uvigo.es

,

Andrea Martínez

Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain Fax: +34(986)812262 Email: yagamare@uvigo.es Email: ggomez@uvigo.es

,

Generosa Gómez*

Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain Fax: +34(986)812262 Email: yagamare@uvigo.es Email: ggomez@uvigo.es

,

Yagamare Fall*

Departamento de Química Orgánica, Facultade de Química, Universidade de Vigo, 36310 Vigo, Spain Fax: +34(986)812262 Email: yagamare@uvigo.es Email: ggomez@uvigo.es

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Abstract

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Abstract

A total synthesis of (+)-muricatacin and a formal synthesis of CMI-977 have been achieved using commercially available l-malic acid based on our furan approach to oxacyclic systems, the proven scope of which is thus broadened.

Key words

butenolide - oxygen - natural products - total synthesis - oxidation

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References

References

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Supplementary Material

Supporting Information