Synlett 2013; 24(12): 1464-1470
DOI: 10.1055/s-0033-1338879
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© Georg Thieme Verlag Stuttgart · New York

Using Chemical Knowledge to Uncover New Biological Function: Discovery of the Cylindrocyclophane Biosynthetic Pathway

Hitomi Nakamura
Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA   Fax: +1(617)4954976   Email: balskus@chemistry.harvard.edu
,
Emily P. Balskus*
Department of Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA   Fax: +1(617)4954976   Email: balskus@chemistry.harvard.edu
› Author Affiliations
Further Information

Publication History

Received: 28 March 2013

Accepted: 02 May 2013

Publication Date:
14 June 2013 (eFirst)

Abstract

An understanding of organic chemistry can play a central role in uncovering enzymes with new biochemical functions. We have recently identified the enzymes involved in the biosynthesis of the cylindrocyclophanes, a structurally unique family of natural products, and found that this pathway employs a remarkable macrocyclization event that requires functionalization of an unactivated carbon atom. This work illustrates the potential of using chemically guided approaches for enzyme discovery.

 
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