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Synthesis 2014; 46(01): 96-100
DOI: 10.1055/s-0033-1338577
DOI: 10.1055/s-0033-1338577
paper
A Convenient Preparation of Thieno[3,2-c]pyrazole[1]
Further Information
Publication History
Received: 08 August 2013
Accepted after revision: 03 October 2013
Publication Date:
28 November 2013 (online)
Abstract
A practical synthesis of multigram quantities of 1H-thieno[3,2-c]pyrazole is presented in which the Jacobson reaction serves as the key step.
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References
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- 4 Current address: 33 Casale Drive South, Warren, NJ 07059, USA.
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- 19 An aliquot was removed and worked up by filtration, concentration of the filtrate, and chromatography of the residue. Combination and concentration of amide-containing fractions gave N-(2-methyl-3-thienyl)acetamide as a light-beige solid. 1H NMR: δ = 2.18 (s, 3 H), 2.31 (s, 3 H), 7.01 (d, 1 H), 7.27 (d, 1 H). 13C NMR: δ = 12.25, 23.73, 120.69, 124.34, 126.10, 131.49, 167.84. Anal. Calcd for C7H9NOS: C, 54.17; H, 5.84; N, 8.78; S, 20.66. Found: C, 53.92; H, 5.86; N, 8.78; S, 20.51.
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For similar alane reductions, see also: