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Synthesis 2013; 45(22): 3164-3172
DOI: 10.1055/s-0033-1338533
DOI: 10.1055/s-0033-1338533
paper
Iron(III) Chloride Catalyzed Synthesis of Functionalized Spiropyrimidines
Authors
Weitere Informationen
Publikationsverlauf
Received: 31. Mai 2013
Accepted after revision: 22. August 2013
Publikationsdatum:
24. September 2013 (online)
Abstract
Potentially bioactive pyrimidine-annulated spiroheterocyclic compounds are synthesized in good to excellent yields using readily available, cheap and environmentally friendly iron(III) chloride (FeCl3) as the catalyst. The process is straightforward and provides a diverse range of spiropyrimidine derivatives via the 5-endo-dig mode of cyclization, starting from simple and easily available starting materials.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information (PDF)
-
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