Synthesis 2013; 45(8): 1051-1059
DOI: 10.1055/s-0032-1318476
paper
© Georg Thieme Verlag Stuttgart · New York

Efficient Transformation of Inactive Nitriles into 5-Substituted 1H-Tetrazoles Using Microwave Irradiation and Their Applications

Hiroki Yoneyama
a  Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan   Fax: +81(72)6901086   Email: harusawa@gly.oups.ac.jp
,
Yoshihide Usami
a  Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan   Fax: +81(72)6901086   Email: harusawa@gly.oups.ac.jp
,
Seiji Komeda
b  Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan
,
Shinya Harusawa*
a  Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan   Fax: +81(72)6901086   Email: harusawa@gly.oups.ac.jp
› Author Affiliations
Further Information

Publication History

Received: 09 January 2013

Accepted after revision: 25 February 2013

Publication Date:
08 March 2013 (online)

Abstract

Efficient transformations of inactive nitriles into 5-substituted 1H-tetrazoles in DMF in a microwave reactor are described. The present method is applied to the synthesis of tetrazolato-bridged dinuclear platinum(II) complex and tetrazole C1-ribonucleoside phosphoramidite.

Supporting Information

 
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