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Synlett 2013; 24(5): 645-651
DOI: 10.1055/s-0032-1318331
DOI: 10.1055/s-0032-1318331
letter
A Simple and Efficient Microwave-Assisted Synthesis of Substituted Isoindolinone Derivatives via Ligand-Free Pd-Catalyzed Domino C–C/C–N Coupling Reaction
Further Information
Publication History
Received: 03 January 2013
Accepted after revision: 12 February 2013
Publication Date:
25 February 2013 (online)


Abstract
We have reported a microwave-assisted, ligand-free Pd-catalyzed domino C–C/C–N coupling reaction to construct diverse isoindolinone derivatives using amides and isocyanides as coupling partners. This strategy provides isoindolinone derivatives in moderate to good yield and high stereoselectivity. A broad range of amides has been tolerated and there is no need for extra-dry conditions in this reaction protocol, which offered highly diverse products and easy handling of the reaction.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information