An Expeditious Enantiospecific Total Synthesis of (–)-Crassalactone C

Abstract

A concise and expeditious approach for the total synthesis of bioactive styryllactone (–)-crassalactone C is presented from tartaric acid. The main features of the synthesis include the desymmetrization of dimethylamide of tartaric acid and the effective use of cinnamoyl ester as a protecting group as well as a reactant in the ring-closing metathesis reaction.

Key words

crassalactone C - natural products - stereoselective synthesis - styryllactone

• References

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For a review on the cytotoxic activity and other bioactivity of styryllactones, see:
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