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Synthesis 2013; 45(4): 471-478
DOI: 10.1055/s-0032-1318106
DOI: 10.1055/s-0032-1318106
paper
Water-Dependent Reduction of Carbohydrate Azides by Dithiothreitol
Further Information
Publication History
Received: 01 November 2012
Accepted after revision: 21 December 2012
Publication Date:
18 January 2013 (online)
Dedicated to Professor Genrikh A. Tolstikov on the occasion of his 80th birthday
Abstract
Dithiothreitol efficiently reduces carbohydrate azides in aqueous acetonitrile to give good-to-excellent yields of the corresponding amines or, after N-acetylation, acetamides. This reduction can proceed in either the presence or the absence of a base.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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