Synlett 2013; 24(1): 61-64
DOI: 10.1055/s-0032-1317693
© Georg Thieme Verlag Stuttgart · New York

An Efficient Access to Aspermytin A and Oblongolide C through an Intramolecular Nitrile Oxide–Alkene [3+2] Cycloaddition

Atsushi Inouea, Makoto Kanematsua, Seiji Morib, Masahiro Yoshidaa, Kozo Shishido*a
  • aGraduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan   Email:
  • bDepartment of Chemistry, Faculty of Science, Ibaraki University, Bunkyo, Mito 310-8512, Japan
Further Information

Publication History

Received: 15 October 2012

Accepted after revision: 05 November 2012

Publication Date:
04 December 2012 (eFirst)


The second generation synthesis of (+)-aspermytin A and the first total synthesis of (–)-oblongolide C have been accomplished employing an intramolecular nitrile oxide–alkene [3+2] cycloaddition as the key step.

Supporting Information