Synlett 2012; 23(20): 2935-2938
DOI: 10.1055/s-0032-1317686
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 4H-Pyrazino[1,2-a]pyrimidine-4,9(8H)-diones and Imidazo[1,2-a]pyrazin-8(7H)-ones

Piotr Raubo*
a   AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire, LE11 5RH, UK   eMail: piotr.raubo@astrazeneca.com
b   AstraZeneca R&D, Alderley Park, Macclesfield, SK10 4TG, UK
,
Neal Ladwa
a   AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire, LE11 5RH, UK   eMail: piotr.raubo@astrazeneca.com
c   Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK
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Received: 06. September 2012

Accepted after revision: 02. November 2012

Publikationsdatum:
28. November 2012 (online)


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Abstract

A facile method of synthesis of 4H-pyrazino[1,2-a]-­pyrimidine-4,9(8H)-diones and imidazo[1,2-a]pyrazin-8(7H)-ones from the corresponding 3-amino-2(1H)-pyrazinones is described.