Step-Efficient Access to Chiral Primary Amines

Abstract

Routes to enantioenriched amines are outlined that employ reductive amination and carbanion addition methods. The strategies require either one or two reaction steps from prochiral carbonyl compounds for the synthesis of the corresponding chiral primary amines.

Key words

chiral amine - enantiopure amines - reductive amination - cuprate addition - imine reduction

• References


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