Synlett 2013; 24(1): 137-138
DOI: 10.1055/s-0032-1317531
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© Georg Thieme Verlag Stuttgart · New York

Manganese(III) Acetate

Manoj Mondal
Department of Chemistry, Dibrugarh University, Dibrugarh 786004, India   Email: manojjmondal@gmail.com
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Further Information

Publication History

Publication Date:
04 December 2012 (online)

Dedicated to my honourable mentor Dr. Utpal Bora

Introduction

Manganese(III) acetate [Mn(OAc)3]-mediated free-radical reactions have emerged as important synthetic methods. Manganese acetate can be used as an oxidizing and chlorinating agent[ 1 ] and in some cases in alkylations[ 1 ] and inter- and intramolecular cyclizations.[ 2 ] Due to the poor solubility of Mn(OAc)3 in common organic solvents, Mn(OAc)3-mediated reactions are often carried out in acetic acid, although other solvents including toluene, alcohols, acetonitrile, dichloromethane and chlorobenzene can be used.[ 3 ] Mn(OAc)3 promotes the synthesis of many alkaloids,[ 4 ] triterpenes,[ 5 ] and drugs.[ 6 ] Mn(OAc)3 is commercially available in form of its dehydrate as a brown powder and can be prepared in the laboratory[ 7 ] by adding KMnO4 to a pre-heated mixture of Mn(OAc)2 and glacial acetic acid (Scheme [1]). Addition of acetic anhydride to the reaction produces the anhydrous form.[ 8 ]

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Scheme 1 Preparation of manganese (III) acetate
 
  • References

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