Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Rhodium Block Copolymer Complexes in Aqueous Micelles

Shlomi Elias; Kerem Goren; Arkadi Vigalok

doi:10.1055/s-0032-1317487

Synlett, Table of Contents

Synlett 2012; 23(18): 2619-2622
DOI: 10.1055/s-0032-1317487

letter

Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Rhodium Block Copolymer Complexes in Aqueous Micelles

Authors

Shlomi Elias

School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel Fax: +972(3)6406205 Email: avigal@post.tau.ac.il
Kerem Goren

School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel Fax: +972(3)6406205 Email: avigal@post.tau.ac.il
Arkadi Vigalok*

School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel Fax: +972(3)6406205 Email: avigal@post.tau.ac.il

Abstract

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Abstract

High activity and enantioselectivity were achieved in the rhodium-catalyzed asymmetric transfer-hydrogenation reactions of ketones in pure water using a novel amphiphilic block polypeptide ligand. The covalent linkage of the catalyst to the block copolymer plays a significant role and provides higher conversions and better recyclability than regular micellar or nonmicellar systems.

Key words

asymmetric transfer hydrogenation - micellar catalysis - block copolymers - ketones - rhodium

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References

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Supplementary Material

Supporting Information (PDF)