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Synthesis 2012; 44(22): 3543-3549
DOI: 10.1055/s-0032-1317472
DOI: 10.1055/s-0032-1317472
paper
Novel One-Pot Synthesis of 2-Substituted 3-Alkoxyisoindolin-1-imine Derivatives from 2-Cyanobenzaldehyde, Amine, and Alcohol
Further Information
Publication History
Received: 09 August 2012
Accepted after revision: 24 September 2012
Publication Date:
16 October 2012 (online)
Abstract
A novel, one-pot procedure has been developed for the synthesis of 2-substituted 3-alkoxyisoindolin-1-imine derivatives via three-component condensation of 2-cyanobenzaldehyde, amine, and alcohol. The efficient and convenient reaction conditions provide the corresponding products from various substrates in good yields (65–96%) catalyzed by acetic acid. The straightforward procedure is a valid contribution to methods for the synthesis of isoindolin-1-imine derivatives.
Key words
2-cyanobenzaldehyde - isoindolin-1-imine - multicomponent reaction - 3-alkoxyisoindolin-1-imineSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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