Synlett 2012; 23(18): 2667-2671
DOI: 10.1055/s-0032-1317344
letter
© Georg Thieme Verlag Stuttgart · New York

An Efficient Method for Phosphorylation of Alcohols: Preparation of Por­phyrin-Derived Phosphates

Sabina Pisarek
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland   Fax: +22(343)2051   Email: dorota.gryko@icho.edu.pl
,
Hubert Bednarski
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland   Fax: +22(343)2051   Email: dorota.gryko@icho.edu.pl
,
Dorota Gryko*
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland   Fax: +22(343)2051   Email: dorota.gryko@icho.edu.pl
› Author Affiliations
Further Information

Publication History

Received: 26 July 2012

Accepted after revision: 10 September 2012

Publication Date:
09 October 2012 (online)


Abstract

An effective method for the phosphorylation of phenols and various alcohols including porphyrins bearing hydroxyl groups was developed. The reaction of 6,7-bis(3-hydroxypropyl)-1,3,5,8-tetramethyl-2,4-divinylporphyrin with dialkyl chlorophosphate in the presence of DABCO as both a catalyst and a proton scavenger gave the desired phosphate in 97% yield.

Supporting Information

 
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