Synlett 2012; 23(16): 2381-2384
DOI: 10.1055/s-0032-1317077
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Polysubstituted Naphthalenes by Iron-Catalyzed [2+2+2] Annu­lation of Grignard Reagents with Alkynes

Authors

  • Laurean Ilies

  • Arimasa Matsumoto

  • Motoaki Kobayashi

  • Naohiko Yoshikai

  • Eiichi Nakamura*

Further Information

Publication History

Received: 26 June 2012

Accepted after revision: 20 July 2012

Publication Date:
03 September 2012 (online)


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Abstract

Iron catalyzes the oxidative [2+2+2] annulation of an ­arylmagnesium compound with two molecules of an internal alkyne via C–H bond activation at 0 °C to produce polysubstituted naphthalene.

Supporting Information