A Convenient One-Pot Synthesis of N-Substituted 2-Aminoazole Derivatives

Abstract

A practical protocol for the one-pot synthesis of N-substituted 2-aminoazole derivatives is described, employing simple azole substrates, nitrogen nucleophiles, lithium tert-butoxide as the base, and iodine to mediate carbon–nitrogen bond formation. This method proceeds at room temperature under an air atmosphere using a normal benchtop set-up, or can be performed conveniently using microwave irradiation.

Key words

N-substituted 2-aminoazoles - iodine - one-pot synthesis - benzoxazole - carbon–nitrogen bond formation

• References


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