Synthesis 2012; 44(23): 3595-3597
DOI: 10.1055/s-0032-1316809
short paper
© Georg Thieme Verlag Stuttgart · New York

An Expedient Synthesis of 2,4,6-Tris(trifluoromethyl)aniline

Brian L. Edelbach
a   Monroe Community College, 1000 East Henrietta Rd., Rochester, NY 14623, USA
,
Blaze M. Pharoah
a   Monroe Community College, 1000 East Henrietta Rd., Rochester, NY 14623, USA
,
Sarina M. Bellows
b   Department of Chemistry, University of Rochester, Rochester, NY 14627, USA   Fax: +1(585)2760205   eMail: holland@chem.rochester.edu
,
Peter R. Thayer
a   Monroe Community College, 1000 East Henrietta Rd., Rochester, NY 14623, USA
,
Charles N. Fennie
a   Monroe Community College, 1000 East Henrietta Rd., Rochester, NY 14623, USA
,
Ryan E. Cowley
b   Department of Chemistry, University of Rochester, Rochester, NY 14627, USA   Fax: +1(585)2760205   eMail: holland@chem.rochester.edu
,
Patrick L. Holland*
b   Department of Chemistry, University of Rochester, Rochester, NY 14627, USA   Fax: +1(585)2760205   eMail: holland@chem.rochester.edu
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Publikationsverlauf

Received: 25. September 2012

Accepted after revision: 23. Oktober 2012

Publikationsdatum:
13. November 2012 (online)


Abstract

A simple two-step synthetic route leads to 2,4,6-tris(trifluoromethyl)aniline. It proceeds through deprotonation and iodination of 1,3,5-tris(trifluoromethyl)benzene, followed by copper-catalyzed amination.

 
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