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Synthesis 2012; 44(15): 2469-2473
DOI: 10.1055/s-0032-1316550
DOI: 10.1055/s-0032-1316550
paper
Reductive Amination by Continuous-Flow Hydrogenation: Direct and Scalable Synthesis of a Benzylpiperazine
Further Information
Publication History
Received: 19 March 2012
Accepted after revision: 18 May 2012
Publication Date:
02 July 2012 (online)


Abstract
A benzylpiperazine was prepared directly from the corresponding benzaldehyde and piperazine on a continuous-flow hydrogenation apparatus. The synthesis was protecting group free, safe, and environmentally friendly. Large-scale synthesis under flow hydrogenation conditions was also demonstrated.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information