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Synthesis 2012; 44(13): 2070-2078
DOI: 10.1055/s-0031-1291160
DOI: 10.1055/s-0031-1291160
paper
Debenzylation of Functionalized 4- and 5-Substituted 1,2,3-Triazoles
Further Information
Publication History
Received: 20 February 2012
Accepted after revision: 23 April 2012
Publication Date:
14 June 2012 (online)
Abstract
A range of 4- and 5-substituted N-benzyl-1,2,3-triazoles have been submitted to debenzylation using Pd/C and hydrogen in the presence of 1,1,2-trichloroethane. Triazoles with oxygen-containing substituents are efficiently debenzylated under these conditions. Triazoles with a phenyl or benzyl substituent on C4 or C5 are not debenzylated, whereas a pentyl-substituted derivative was readily debenzylated.
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