Towards an Efficient Preparation of Hydromorphone

Dedicated to Prof. Dr. Wolf-Dieter Rudorf on the occasion of his 70^th birthday. Ad multos annos!

Abstract

Dihydromorphone was prepared from morphine in high yield, excellent purity, and low residual metal content. The key steps used palladium on porous glass and a modified Oppenauer oxidation, or Wilkinson’s catalyst.

Key words

alkaloids - catalysis - oxidation - reduction - supported catalysis

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