Synthesis 2012; 44(22): 3441-3446
DOI: 10.1055/s-0031-1291139
practical synthetic procedures
© Georg Thieme Verlag Stuttgart · New York

Convenient One-Pot Two-Step Synthesis of 1,3-Thiazoles via Organocatalyzed Epoxidation of Nitroolefins

Shengwei Wei
Department of Chemistry and Pharmacy, Institute of Organic Chemistry 1, University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany, Fax: +49(9131)8526865   Email: tsogoeva@chemie.uni-erlangen.de
,
Katharina M. Weiß
Department of Chemistry and Pharmacy, Institute of Organic Chemistry 1, University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany, Fax: +49(9131)8526865   Email: tsogoeva@chemie.uni-erlangen.de
,
Svetlana B. Tsogoeva*
Department of Chemistry and Pharmacy, Institute of Organic Chemistry 1, University of Erlangen-Nuremberg, Henkestraße 42, 91054 Erlangen, Germany, Fax: +49(9131)8526865   Email: tsogoeva@chemie.uni-erlangen.de
› Author Affiliations
Further Information

Publication History

Received: 20 March 2012

Accepted: 22 March 2012

Publication Date:
04 July 2012 (online)


Abstract

A convenient novel one-pot two-step strategy and its substrate scope for the synthesis of 1,3-thiazole heterocycles via organocatalytic epoxidation of nitroolefins with the TBHP/DBU system, and subsequent reaction of α-nitroepoxides with thioamides is reported.

 
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