Easy Synthesis of Novel 4-Azolylpyridazin-3-ones
27 March 2012 (eFirst)
Ethyl azol-2-ylglyoxylates react smoothly with acetone in the presence of catalytic amounts of proline and trifluoroacetic acid to give the corresponding azolyl aldols in 93-98% yield. The products are easily transformed into azolyl pyridazinones in 85-98% yield by cyclization with hydrazine hydrate.
heterocycles - cyclizations - pyridazines - ketones - esters - catalysis