Synlett 2012(4): 642-643  
DOI: 10.1055/s-0031-1290334
SPOTLIGHT
© Georg Thieme Verlag Stuttgart ˙ New York

Zinc Borohydride

Ivson Lelis Gama*
Instituto de Química, Universidade Federal Fluminense, UFF, CEP: 24020-141 Niterói, Rio de Janeiro, Brazil
e-Mail: ivsonlelis@yahoo.com.br;
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Publikationsverlauf

Publikationsdatum:
13. Februar 2012 (online)

Introduction

Zinc borohydride is a neutral reagent employed for the reduction of several types of carbonyl compounds. It is commercially available, but it is also easily prepared by reacting ZnCl2 with NaBH4. [¹] Kotsuki et al. described the selective reduction of thioesters in the presence of other functional groups using Zn(BH4)2 [¹] and Oishi and Nakata described the reduction of chiral β-keto esters with Zn(BH4)2 leading to the corresponding alcohols with high stereoselectivity. [²] This Spotlight summarizes further ­reactions of zinc borohydride.

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