Synlett 2012(3): 438-442  
DOI: 10.1055/s-0031-1290312
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Ring Opening of Aminocyclopropyl Ugi Adducts

Aurélie Dos Santos, Laurent El Kaïm*, Laurence Grimaud*, Romain Ramozzi
Laboratoire DCSO ENSTA-Polytechnique-CNRS, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France
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Further Information

Publication History

Received 14 November 2011
Publication Date:
19 January 2012 (eFirst)


The ring opening of aminocyclopropanes triggered by activation with an intramolecular arylpalladium(II) iodide complex is an interesting strategy for the synthesis of nitrogen heterocycles and a valuable Ugi postcondensation-type transformation. Six- and seven-membered-ring cyclic enamines may be obtained.