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Synlett 2012(2): 311-313  
DOI: 10.1055/s-0031-1290076
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthetic Approach to the Chemical Isostere of O-Methyl Honokiol

Minghua Cui, Hak Sung Kim*
Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, 344-2 Shinyong-Dong, Iksan, Jeonbuk 570-749, South Korea
Fax: +82(63)8431581; e-Mail: hankidad@wku.ac.kr;
Further Information

Publication History

Received 19 September 2011
Publication Date:
03 January 2012 (online)

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Abstract

We established a synthetic method for the chemical isostere of the structurally unique natural product, 4′-O-methyl honokiol by replacing two allyl groups with two different alkyl groups with the aim of developing synthetic analogues of the chemical isostere. The key steps in this synthetic route are the Suzuki-Miyaura coupling reaction for the formation of the phenylpyridine moiety and the Stille coupling reaction for the stepwise introduction of two allyl groups.

Key words

honokiol - 4′-O-methyl honokiol - chemical isostere - Suzuki-Miyaura coupling - Stille coupling

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