Synthesis of Complex Glycosylated Carboranes for BNCT

Abstract

An efficient strategy for the preparation of carboranyl derivatives from a common intermediate containing a sugar moiety functionalized with an azido group is described. Such compounds should allow either the conjugation with peptides or proteins for an improved delivery of the products, or the monitoring of the biodistribution profile.

Key words

BNCT - glycosyl carboranes - labeling - dansyl - nitroxide

References and Notes

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7

All new compounds gave satisfactory elemental analysis and spectroscopic data (see Supporting Information).