Synthesis 2012; 44(15): 2359-2364
DOI: 10.1055/s-0031-1289812
paper
© Georg Thieme Verlag Stuttgart · New York

A New Approach to the Synthesis of Acyclic Nucleotide Phosphonate Analogues with Triple or Double Bonds

Valery K. Brel*
Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka, Moscow Region 142432, Russian Federation, Fax: +7(495)7857024   Email: brel@ipac.ac.ru
› Author Affiliations
Further Information

Publication History

Received: 26 March 2012

Accepted after revision: 14 May 2012

Publication Date:
26 June 2012 (online)


Abstract

On the basis of new methodology to design the phosphonate analogues of nucleotides, the first series of acyclic nucleotides possessing a triple bond in the carbon skeleton were prepared by coupling diethyl 4-chlorobuta-1,2-dienylphosphonate with the corresponding purine or pyrimidine nucleic bases under base-catalyzed alkylation conditions.

 
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