Scale-Up of Flow-Assisted Synthesis of C 2-Symmetric Chiral PyBox Ligands
25 January 2012 (eFirst)
A series of PyBox ligands were prepared from commercially available chelidonic acid by a multistep flow sequence using mesoreactor technology. A chloro group introduced onto the ligand scaffold was subsequently exploited to give amine derivatives ready for immobilization through microencapsulation technologies.
ligands - macrocycles - flow chemistry - solid-supported reagent - asymmetric synthesis - scale up