Abstract
A general method for the conversion of N -Boc
amino acids into their homologated α-hydroxy-β-Fmoc
amino acids is described. The protocol involved preparation of the
amino aldehyde by reduction of the corresponding Weinreb amides,
hydrocyanation, and hydrolysis of the nitrile group, followed by
reprotection of the amino acid as the Fmoc derivative.
Key words
N -Boc amino acid - reduction - hydrocyanation -
N -Fmoc
amino acid
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