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Synfacts 2011(12): 1382-1382  
DOI: 10.1055/s-0031-1289422
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Disulfide Bond Formation with Polymer-Supported Reagent

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Heeyoel Baek
P. Verdié, L. Ronga, M. Cristau, M. Amblard, S. Cantel, C. Enjalbal, K. Puget, J. Martinez*, G. Subra*
Institut des Biomolecules Max Mousseron IBMM, Montpellier and Genepep, Domaine des Pins, Saint Clement de Riviere, France
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

Oxidizing reagents for disulfide formation of peptides are prepared from poly(ethylene glycol)polyacrylamide (PEGA) via the stepwise solid-phase peptide synthesis (method 1) or the oligomerization of N-carboxy anhydride derivatives (method 2). The oxidation of peptides 1 and 2 was carried out with resins 1a-d and 2 to give the corresponding disulfides 1′ and 2′ in 90-100% yield.