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Synfacts 2011(12): 1341-1341  
DOI: 10.1055/s-0031-1289365
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Optically Pure Bulky Carbinols via Kinetic Resolution

Contributor(s): Mark Lautens, Patrick T. Franke
B. Hu, M. Meng, J. S. Fossey, W. Mo, X. Hu, W.-P. Deng*
East China University of Science and Technology, Shanghai, P. R. of China
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Publikationsdatum:
18. November 2011 (online)

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Significance

The authors have previously developed a remarkably effective planar chiral PIP catal­yst for the catalytic kinetic resolution of bulky aryl­alkyl carbinols to afford the corresponding esters with high enantioselectivity (J. Am. Chem. Soc. 2010, 132, 17041). In the present work they report the application of this system to bulky (hetero)-arylalkyl carbinols affording alcohols in near ideal conversions with excellent enantioselectivities.