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Synfacts 2011(12): 1355-1355
DOI: 10.1055/s-0031-1289357
DOI: 10.1055/s-0031-1289357
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Difluoromethylation of Carbonyls and Imines with TMSCF2H
Y. Zhao, W. Huang, J. Zheng, J. Hu*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
An efficient and direct nucleophilic difluoromethylation using (difluoromethyl)trimethylsilane in the presence of a Lewis base is disclosed. Several carbonyl compounds as well as sulfinyl imines are successfully converted into the corresponding difluoromethylated derivatives.