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Synfacts 2011(12): 1348-1348
DOI: 10.1055/s-0031-1289349
DOI: 10.1055/s-0031-1289349
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Intramolecular Oxidative Cyclization
Z.-Q. Wang, W.-W. Zhang, L.-B. Gong, R.-Y. Tang, X.-H. Yang, Y. Liu, J.-H. Li*
Hunan University, Changsha, Hunan Normal University, Changsha and Wenzhou University, P. R. of China
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
In this work the first example of a copper(II)-catalyzed oxidative cyclization of enynes is disclosed. This 6-exo-trig cyclization reaction is facilitated by Ce(SO4)2 and uses molecular oxygen as oxidant. A variety of substituents on the substrates are tolerated under the mild reaction conditions. The obtained 1,4-naphthoquinones are important structural units in natural products.