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Synfacts 2011(12): 1343-1343  
DOI: 10.1055/s-0031-1289345
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Enantioselective γ-Alkylation of Carbonyl Compounds

Contributor(s): Paul Knochel, Andreas K. Steib
S. L. Zultanski, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

The authors describe a new method for the catalytic enantioselective γ- (and δ-)alkyl­ation of carbonyl compounds by cross-coupling of γ- (and δ-)haloamides with alkylboranes. The reaction is catalyzed by nickel and uses a commercially available chiral diamine ligand to achieve high enantiomeric excess.