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Synfacts 2011(12): 1265-1265
DOI: 10.1055/s-0031-1289342
DOI: 10.1055/s-0031-1289342
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (+)-Ophiobolin A
K. Tsuna, N. Noguchi, M. Nakada*
Waseda University, Tokyo, Japan
Further Information
Publication History
Publication Date:
18 November 2011 (online)
Significance
(+)-Ophiobolin is a naturally occurring sesterterpene isolated from the pathogenic plant fungus Ophiobolus miyabeanus in 1958. It exhibits bioactivity against a range of nematodes, fungi, and bacteria. Herein, the first total synthesis of (+)-ophiobolin is reported.