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Synfacts 2011(12): 1334-1334  
DOI: 10.1055/s-0031-1289327
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Asymmetric Henry Reaction

Contributor(s): Hisashi Yamamoto, Susumu Oda
Y. Q. Ji, G. Qi, Z. M. A. Judeh*
Nanyang Technological University, Singapore
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

Chiral N-alkyl-C 1-tetrahydro-1,1′-bisisoquinolines are promising ligands due to their tunable bite angle through the substituent on the sp³ nitrogen. In this paper, the authors developed an effective copper catalyst for the asymmetric Henry reaction using the C 1-tetrahydro-1,1′-bis­isoquinoline ligand.