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Synfacts 2011(12): 1273-1273
DOI: 10.1055/s-0031-1289320
DOI: 10.1055/s-0031-1289320
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New YorkSynthesis of BIRT2584
X.-J. Wang*, R. P. Frutos et al.*
Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, USA; Boehringer Ingelheim Gmbh & Co KG, Ingelheim, Germany
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Publikationsverlauf
Publikationsdatum:
18. November 2011 (online)
Significance
BIRT2584 inhibits lymphocyte function-associated antigen-1 (LFA-1). It is under development for the treatment of immune ailments, such as psoriasis and rheumatoid arthritis. The synthesis depicted was accomplished on a metric ton scale and features the use of Seebach’s self-regeneration of stereocenters protocol to install the single stereogenic center in E.