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Synfacts 2011(12): 1276-1276  
DOI: 10.1055/s-0031-1289316
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of MK-8245

Contributor(s): Philip Kocienski
M. Girardin, S. J. Dolman*, S. Lauzon, S. G. Ouellet, G. Hughes, P. Fernandez, G. Zhou, P. D. O’Shea
Merck Frosst Centre for Therapeutic Research, Kirkland, Canada; Merck Sharp and Dohme Corporation, Rahway, USA
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Publication History

Publication Date:
18 November 2011 (online)

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Significance

Stearoyl-CoA desaturase 1 (SCD-1) is implicated in the biosynthesis of monounsaturated fatty acids that are essential components of membrane phospholipids, cholesterol esters, and triglycerides. MK-8245 is a liver-targeted SCD-1 inhibitor with potential for the treatment of type-2 diabetes, dyslipidemia, and obesity.