DMW - Deutsche Medizinische Wochenschrift, Table of Contents Dtsch Med Wochenschr 2010; 135(47): 2371DOI: 10.1055/s-0030-1269403 Pro & Contra | CommentaryIntensivmedizin© Georg Thieme Verlag KG Stuttgart · New YorkAktiviertes Protein C im septischen Schock – contraActivated protein C in patients with septic shock: contraJ. Graf1 1Medizinischer Dienst, Aero Medical Center, Deutsche Lufthansa AG, Frankfurt Recommend Article Abstract Buy Article Schlüsselwörter aktiviertes Protein C - Drotrecogin alfa - Sepsis - septischer Schock Keywords aktivated protein C - drotrecogin alfa - sepsis - septic shock Full Text References Literatur 1 Angus D C. et al. PROWESS Investigators . The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med. 2004; 32 2199-2206 2 Bernard G R. et al . Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group.. N Engl J Med. 2001; 344 699-709 3 Brunkhorst F M. et al, German Sepsis Competence Network (SepNet) . Practice and perception. Crit Care Med. 2008; 36 2719-2725 4 Eichacker P Q, Natanson C. Increasing evidence that the risks of rhAPC may outweigh its benefits. Intensive Care Med. 2007; 33 396-399 5 Gao F. et al . The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis. Crit Care. 2005; 9 R764-R770 6 Martí-Carvajal A, Salanti G, Cardona A F. Human recombinant activated protein C for severe sepsis. Cochrane Database Syst Rev. 2007 CD004388; 7 Poeze M. et al . An international sepsis survey: a study of doctors’ knowledge and perception about sepsis. Crit Care. 2004; 8 R409-R413 Priv.-Doz. Dr. med. Jürgen Graf Medizinischer DienstAero Medical CenterDeutsche Lufthansa AGLufthansa Basis, Tor 21 60546 Frankfurt am Main und Medizinische FakultätPhilipps-Universität Marburg Baldingerstraße 35043 Marburg