Psoriasis als unabhängiger Risikofaktor für die Entwicklung einer koronaren Herzkrankheit

Zusammenfassung

Psoriasis ist eine chronisch-entzündliche Dermatose mit schubweisem Verlauf. Die bekannteste Komorbidität stellt die Psoriasisarthritis dar. Im klinischen Alltag fällt auf, dass Psoriasispatienten häufiger klassische kardiovaskuläre Risikofaktoren wie Adipositas, Diabetes mellitus, Hyperliproteinämie, arterielle Hypertonie, Nikotinabusus bis hin zum Metabolischen Syndrom aufweisen und häufiger an koronarer Herzerkrankung leiden als Nichtpsoriatiker. Dies konnte durch zahlreiche klinische und epidemiologische Studien belegt werden. In den letzten Jahren kristallisiert sich zunehmend die Rolle der Psoriasis als eigenständiger kardiovaskulärer Risikofaktor heraus, unabhängig von begleitenden klassischen Risikofaktoren. Dieser Artikel fasst den bisherigen Stand der Kenntnisse zur Komorbidität zwischen Psoriasis und koronarer Herzerkrankung zusammen und diskutiert mögliche gemeinsame immunpathologische Mechanismen.

Abstract

Psoriasis is a chronic inflammtory dermatosis with a relapsing course. The best known comorbidity is psoriatic arthritis. In daily clinical practise it is well known, that patients with psoriasis show more often classic cardiovaskular risk factors such as obesity, Diabetes mellitus, hyperlipoproteinemia, hypertension, nicotine abuse often presenting as Metabolic Syndrome and suffer more often from coronary heart disease than patients without psoriasis. This could be demonstraded in numerous clinical and epidemiologic studies. In the last few years there is increasing evidence for psoriasis beeing an independent cardiovascular risk factor despite of concomitant classic risk factors. This review summarizes the current state of research and discusses possible common immunpathogenetic mechanisms.

Schlüsselwörter

Psoriasis - koronare Herzkrankheit - Myokardinfarkt - Risikofaktoren - Entzündung

Keywords

Psoriasis - coronary artery disease - myocardial infarction - risk factors - inflammation

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