Synthesis 2011(18): 2935-2940  
DOI: 10.1055/s-0030-1261032
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Assisted Synthesis of 5-Substituted 2-Aminothiophenes Starting from Arylacetaldehydes

Germain Revelant, Sandrine Dunand, Stéphanie Hesse*, Gilbert Kirsch
Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, FR CNRS 2843, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)87325801; e-Mail: hesse@univ-metz.fr;
Further Information

Publication History

Received 29 April 2011
Publication Date:
05 August 2011 (online)

Abstract

An easy three-step pathway for the synthesis of arylacet­aldehydes from the corresponding carboxylic acids in very high yields is described. Their use as precursors of 5-substituted-2-aminothiophenes is illustrated via a microwave-assisted Gewald reaction. This method allows obtaining the expected compounds in a shorter time and with better yields and purities than the classical procedures.