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Synlett 2011(13): 1831-1834
DOI: 10.1055/s-0030-1260961
DOI: 10.1055/s-0030-1260961
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Highly Regioselective and Efficient Synthesis of Aminoepoxides by Ring Closure of Aminohalohydrins Mediated by KF-Celite
Further Information
Received
3 March 2011
Publication Date:
21 July 2011 (online)
Publication History
Publication Date:
21 July 2011 (online)
Abstract
The regioselective synthesis of several aminoepoxides has been achieved without observing any trace of azetidinols, which are usually reported as the exclusive reaction products when aminohalohydrins are treated with bases. The use of the mild supported base KF-Celite in refluxing acetonitrile is crucial for modulating the excellent regioselectivity observed.
Key words
epoxides - amino alcohols - regioselectivity - ring closure - epoxidation
- Supporting Information for this article is available online:
- Supporting Information
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